Jobs -> East Carolina University

Business Name East Carolina University
Your Business Type Academia
Logo / Photo
Contact Details
Contact Name Lisandra de Castro Brás
Position (Director / Supervisor / etc) Assistant Professor
Website URL ulty/decastrobrasl14.cfm
Email decastrobrasl14(at)
Office Address
City / Town Greenville
Province/ State NC
Country USA
About Dr. Brás was trained in cardiovascular aging and ventricular remodeling at The Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center at San Antonio (UTHSCSA) and Mississippi Medical Center. She was also trained for 4 years in proteomic-based approaches in one of the seven NHLBI National Proteomics Centers, the San Antonio Proteomics Center at UTHSCSA. The main focus of her research is myocardial remodeling, particularly how the cardiac extracellular matrix (ECM) remodels with age and post-myocardial infarction (MI), and the resulting effects on cardiac function. For this purpose, her lab uses physiological, proteomic, and genomic approaches to investigate the mechanisms underlying left ventricular remodeling. In particular, we study how the cellular and molecular composition of the left ventricle (LV) changes with age, and how subsequent changes to the ECM proteome affect LV structure, integrity, and function. The dynamic interaction between cardiac cells and ECM directly dictates the shape, composition, and function of the LV. The American demographics increasingly shift towards an elderly population and age is an independent risk factor for higher incidence of cardiovascular disease, including MI. Though current therapies have improved survival rates after MI, heart failure remains particularly high in the elderly with ~50% mortality within 5 years. Thus, her research aims to understand the mechanisms behind cardiac aging and how age impacts cardiac healing after MI to improve patient outcomes. It is of upmost importance to understand the mechanisms of scar formation post-MI as a means to identify triggers that lead to heart failure and develop strategies to diagnose, slow, or reverse the progression to heart failure in the elderly

Listing jobs posted by East Carolina University

Listing 427 jobs posted within 1600 days!

Date Description Location
Oct-24-2016 Postdoctoral fellow
Posted By: East Carolina University Category: Full-time
The Laboratory of Dr. Lisandra de Castro Brás in the Brody School of Medicine at East Carolina University, is seeking a motivated Postdoctoral Resear...
Greenville, NC
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