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PIN1 functions in ovarian cancer -AIRC funded Project

Posted by: Ca' Foscari University

Posted date: Mar-02-2020

Location: Venice

High-grade serous ovarian cancer (HGSOC) is the most frequent histotype of ovarian cancers. Although the majority of such patients have no evidence of disease after treatment, about 70% of women have a relapse within 3 years. Tumor heterogeneity and chemoresistance are the major causes of therapeutic failure. The peptidyl prolyl cis-trans isomerase (PPIase) NIMA-interacting 1 (PIN1) controls multiple pathways essential for HGSOC, which inhibition could be important for an innovative target therapy. The project aims to:
1. to establish PIN1 as a booster of HGSOC oncogenesis utilizing normal organoids derived from fallopian tubes. 2. to identify the molecular pathways modulated by PIN1 activity in HGSOC patient-derived tumoroids. 3. to validate the reliability of tumoroids to mimic patients platinum responsiveness.
It will be tested combinatorial therapies with standard and innovative targeted therapies including PIN1.
Job Title PIN1 functions in ovarian cancer -AIRC funded Project
Post Details
Email flavio.rizzolio(at)unive.it
Employer's Website www.unive.it
Category
Job Discipline Job Discipline -> Cancer/Oncology
Job Classification Job Classification -> Postdoctoral Researcher
Job Type Job Type -> Full-time
Location Venice
Key Words postdoc, ovarian cancer, organoids, mouse models, therapy
Start Date 01 April 2020
Salary 30000
Deadline Mar-17-2020