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Research Scientist I, Formulation & Process DevelopmentPosted by: ChemoCentryx
Posted date: Oct-01-2019
Location: Mountain View, CA
ChemoCentryx is offering a unique opportunity for a highly motivated researcher to join our team, which is focused on the discovery and development of orally, parenteral and topical administered therapeutics to treat autoimmune diseases, inflammatory disorders and cancer. The ideal candidate will have significant experience in small molecule formulation preparation and development.
The primary role of this position is to provide pharmaceutics support for the development and preparation of formulations for new chemical entities from pre-clinical to IND and to advanced clinical development in Phase 2 and 3.
Design and conduct pre-formulation assessment studies of various novel drug candidates
Responsible for the development and evaluation of oral and parenteral dosage forms primarily in support of pre-clinical studies
The successful candidate will be responsible for preparation and timely delivery of formulations in support of efficacy, pharmacokinetic, pharmacology and toxicology studies
Responsibilities include managing and supporting in-house stability studies
The successful candidate will be responsible for evaluation and developing prototypes in support of clinical studies in different oral dosage forms (such as powder-in-bottle, liquid suspension, modified release technologies and solubility-enhancing platform), as well as parenteral dosage forms
The successful candidate is expected to have strong hands-on experience on analytical testing methods for drug product
The candidate will have opportunity to support drug product technology transfer from in¬≠ house ‚proof-of-concept‚ prototypes to CRO clinical manufacturing sites, serve as the technical representative during manufacturing operations and participate in technical troubleshooting, review manufacturing batch records and CMO summary reports
Responsible for maintaining accurate laboratory data records and expected to summarize data regularly
Maintaining good operating condition of equipment and observing safety laboratory guidelines
The successful candidate must be self-motivated and organized, enjoy scientific investigation and thinking, proactively identify issues, and develop solutions
Ph.D. degree in a Pharmaceutics, Pharmacy or other related scientific discipline
Direct hands-on experience with HPLC, XRPD, DSC, TGA, light microscopy, particle-size distribution, density, and pH meter
Experience on diverse oral drug product manufacturing unit operations: granulation, spray drying, encapsulation, tableting, film-coating, lyophilization, and sterilization procedure
Experience on developing parenteral formulation
Experience on measuring kinetic and equilibrium solubility in different media
Solid knowledge on dissolution and disintegration testing for solid dosage form
Effective communication skills are important to interact with scientists in a highly interdisciplinary and collaborative research environment
Independent worker who is willing to take on new responsibility and to learn new skills
Good team player who is willing to listen and understand different specific formulation needs of discovery team members
Exceptional oral communication and writing skills
As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‚EEO is the Law‚ poster.
In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans‚ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careerschemocentryx.com for assistance.