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Process Development EngineerPosted by: RegeneronPosted date: Aug-02-2010
Location: Tarrytown, NY 10591
Regeneron is a biopharmaceutical Company that discovers, develops, and commercializes therapeutic medicines for the treatment of serious medical conditions. Regeneron currently markets ARCALYST (rilonacept) Injection for subcutaneous use for the treatment of a rare, inherited, inflammatory condition. The company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases and inflammatory diseases, and has preclinical programs in other diseases and disorders.
With a strong research base and product focus, Regeneron is able to understand thoroughly the biology of specific disease states, discover potential therapeutic candidates and evaluate product candidates in clinical trials. Regeneron has developed several proprietary platform technologies, which it has incorporated into a comprehensive system that allows it to accelerate the discovery and design of fully human antibodies and move these candidates rapidly into clinical development.
We are seeking a Process Development Engineer to work in the Purification area of the Pre-Clinical Manufacturing and Process Development Group. This person will be involved in the development of protein purification steps, scale-up from bench to pilot scale, and process transfer to Regeneron's Manufacturing Division. Additional responsibilities include preparations for and participation in viral clearance studies supporting the developed processes as well as purification of development and non-development candidate molecules to support reagent needs for Regeneron's basic research groups. It should be expected to travel up to 20% of the time.
- Develop protein purification steps with particular emphasis on rapid development, yield, process economics, and the ability of the process to be run at production scale. Apply these steps to purify protein on the milligram to 500 g scale.
- Prepare for and participate in viral clearance studies conducted off site. Should expect to travel for the majority of this time, i.e. a total of 15 '20 % of the time
- Perform key assays to characterize purified material.
- Assist in the transfer of each process to Rensselaer Manufacturing.
- Assist with the small-scale validation of key process steps for clearance of critical impurities, including media components and viral particles.
- Purification of development and non-development candidate molecules to support reagent needs for Regeneron's basic research groups.
- Compile and analyze data, maintain a quality, up-to-date lab notebook, development reports and other technical documents and prepare for presentations.
Experience:
The ideal candidate will have a Bachelors or Masters degree in Chemical Engineering with a concentration in biochemistry and 0 - 5 years experience in the biotech or pharmaceutical industry. Knowledge and experience with bioseparations processes is preferred.
We offer an extremely competitive compensation and benefits package including stock incentives, 401k with company match as well as the expected health and welfare benefits. Comprehensive relocation benefits are available, as required.
EOE/M/F/D/V
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