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Scripps FL - Sundrud Lab Post-Doc Position

Posted by: The Scripps Research Institiute

Posted date: Apr-23-2019

Location: Jupiter, FL

<p style="box-sizing: inherit; margin: 0px 0px 1.6em; font-family: " droid="" new="">This appointment will focus on the local regulation of mucosal T cell function by bile acids in the small intestine. The Sundrud lab has recently demonstrated that circulating T cells sense and respond to the presence of locally-reabsorbed bile acids in the ileum to maintain homeostasis and suppress the development of small bowel inflammatory disease <a href="https://www.cell.com/immunity/fulltext/S1074-7613(17)30489-2" target="_blank" rel="noopener noreferrer" style="box-sizing: inherit; color: rgb(153, 66, 0); text-decoration: none; transition: all 0.1s ease-in-out;">(<span class="caps" style="box-sizing: inherit;">PMID</span>: 29262351)</a>; the lab has new R01-level funding to explore the T cell-intrinsic functions of ligand-operated nuclear receptors in T cell-bile acid cross-talk in the intestine.</p>
<p style="box-sizing: inherit; margin: 0px 0px 1.6em; font-family: " droid="" new="">The successful candidate will contribute to all aspects of the project, including both in vitro and in vivo T cell analyses, molecular cloning, retroviral T cell transduction experiments, as well as execution and analysis of high-content flow cytometry, <span class="caps" style="box-sizing: inherit;">RNA</span>-seq, <span class="caps" style="box-sizing: inherit;">DNA</span>-seq and <span class="caps" style="box-sizing: inherit;">ATAC</span>-seq experiments. Experience with cloning, T cell culture, animal models of autoimmune and chronic inflammation, and next-generation sequencing is required. Expertise in <span class="caps" style="box-sizing: inherit;">CRISPR</span>/Cas9 gene editing, shRNAmir-mediated gene knockdown and bile acid physiology are preferred but not required. The successful candidate must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.</p>
<p style="box-sizing: inherit; margin: 0px 0px 1.6em; font-family: " droid="" new="">The successful candidate will work in a fast-paced and dynamic group environment and will be supported by a full-time Senior Research Assistant. Here the Florida campus of The Scripps Research Institute offers strong, well resourced, collabrative science and a high quality-of-life in the beachfront town of Jupiter, Florida. Please apply using the Scripps website.</p>
Job Title Scripps FL - Sundrud Lab Post-Doc Position
Post Details
Email adelmas(at)scripps.edu
Employer's Website https
Job Discipline Job Discipline -> Immunology
Job Classification Job Classification -> Postdoctoral Researcher
Job Type Job Type -> Full-time
Location Jupiter, FL
Key Words postdoc, immunology, t cell biology, RNA sequencing
Start Date Open until filled