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Post-doc position: Impact of a fungal probiotic on the gut microbiota in basal, and induced dysbiotic environments

Posted by: INRA

Posted date: Nov-09-2018

Location: Jouy en Josas, France

<p class="MsoNormalCxSpFirst" align="center" style="text-align:center;line-height:
normal"><b><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US"> </span></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="text-align:center;line-height:
normal"><b><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US">Post-doctoral position for two years</span></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="text-align:center;line-height:
normal"><b><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US">in INRA (Jouy-en-Josas, France):</span></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="text-align:center;line-height:
normal"><b><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US"> </span></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="text-align:center;line-height:
normal"><b><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-GB;mso-fareast-language:FR">Impact of a fungal probiotic on the gut microbiota in basal, and induced dysbiotic environments</span></b></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB"> </span></b></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="mso-bidi-font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB">Employer:</span></b></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><span lang="EN-GB" style="mso-bidi-font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-font-weight:bold">A 2 years Postdoctoral position is available starting in February-March 2019 in our Institute (INRA Jouy en Josas). Our researches aim at understanding how the fungal and bacterial gut microbiota and the host interact in a variety of conditions from broad-spectrum antimicrobial treatments, intestinal inflammation or diet modifications. The comprehension of these relationships will help us design new approaches for diseases remediation. Eventually our research will provide means for development of next generation probiotics. We offer a stimulating scientific environment in a young team with state of the art equipment (germ-free/conventional animal platforms, microscopy, proteomics and genomics facilities), and a very active international and collaborative network.</span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="mso-bidi-font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB"> </span></b></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="mso-bidi-font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB">Scientific goal and Strategy</span></b><span lang="EN-GB" style="mso-bidi-font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB">:</span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><span lang="EN-GB" style="mso-bidi-font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB">The intestinal microbiota has been showed to play major roles in human physiology as well as in numerous diseases. Although the bacterial part of the gut microbiota has started to be studied in different pathology, very little data is available regarding the fungal part. In this project we will study more particularly how the fungal microbiota is impacted by a broad-spectrum antimicrobial treatments. And how both fungal and bacterial microbiota are influenced by the use of a fungal probiotic. Similar approaches will also be applied to </span><span lang="EN-GB" style="font-family:Arial;
mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-GB">describe the interkingdom relationship and the effect of antibiotics and fungal probiotic in an already disturbed environment such as a host with a metabolic syndrome.</span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-US">Wild type, KO mice will be used in combination with bacterial and fungal microbiota genomic analyses, metatranscriptomics and targeted metabolomics</span><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB">. Mice models of metabolic disease will also be used.</span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB"> </span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB">Partners involved</span></b><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-GB">: The position is a two-year appointment funded through collaboration between a private company and INRA, INSERM, UPMC and APHP.</span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><span lang="EN-IE" style="font-family: Arial;">The postdoctoral scientist will work in Harry’s Sokol group in the Probihote team (</span><a href="https://www.micalis.fr/Poles-et-Equipes/Pole-Ecosystemes-Alimentaires-et-Digestifs/Interactions-des-Bacteries-Commensales-et-Probiotiques-avec-l-Hote-Philippe-Langella/Organisation/Harry-Sokol"><span lang="EN-IE" style="font-family:Arial;mso-ansi-language:EN-IE">www.micalis.fr/</span></a><span class="MsoHyperlink"><span lang="EN-IE" style="font-family: Arial;"> </span></span><span lang="EN-IE" style="font-family: Arial;">and </span><a href="https://sites.google.com/site/harrysokol/"><span lang="EN-IE" style="font-family:Arial;mso-ansi-language:EN-IE">Site Google-Harry Sokol</span></a><span lang="EN-IE" style="font-family: Arial;">)  of the INRA research center of Jouy-en-Josas (close to Paris) and in close collaboration with the INSERM U1157 lab (Saint Antoine Hospital, Paris). The position is vacant from February 2019 on </span><span class="pages"><span lang="EN-GB" style="font-family:Arial;mso-ansi-language:EN-GB">a</span></span><span lang="EN-IE" style="font-family: Arial;"> full-time basis.</span></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB"> </span></b></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b><span lang="EN-GB" style="font-family:Arial;
mso-ansi-language:EN-GB">Required skills:</span></b><b><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-US"></span></b></p>
<p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><span lang="EN-US" style="font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-US">The project will require a wide variety of techniques including animal experimentation, microbiology, 16S and ITS2 microbiota sequence analysis, transcriptomic analysis, immunology, and metabolism. The candidate should have a recent PhD, be technically accomplished and have a strong knowledge in animal experimentation and at least basic skills in microbiology. Skills in microbiota studies (bioinformatics) would be a strong additional asset. The candidate should have the required authorization to perform animal experiments.</span></p>
<p class="MsoNormalCxSpMiddle" align="center" style="mso-margin-top-alt:auto;
mso-margin-bottom-alt:auto;mso-add-space:auto;text-align:center;line-height:
normal"><b><i><span lang="EN-GB" style="font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:FR"> </span></i></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="mso-margin-top-alt:auto;
mso-margin-bottom-alt:auto;mso-add-space:auto;text-align:center;line-height:
normal"><b><i><span lang="EN-GB" style="font-size:10.0pt;font-family:Arial;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:FR"> </span></i></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="mso-margin-top-alt:auto;
mso-margin-bottom-alt:auto;mso-add-space:auto;text-align:center;line-height:
normal"><b><span lang="EN-GB" style="font-size:10.0pt;font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB;mso-fareast-language:FR">Highly motivated candidates can send an application including a cover letter, a curriculum vitae and the names of (at least) two referees. </span></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="mso-margin-top-alt:auto;
mso-margin-bottom-alt:auto;mso-add-space:auto;text-align:center;line-height:
normal"><b><span lang="EN-GB" style="font-size:10.0pt;font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB;mso-fareast-language:FR">Applications should be sent by email to Mathias Lavie-Richard before January 25th 2017.</span></b><b><span lang="EN-US" style="font-size:10.0pt;
font-family:Arial;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US;mso-fareast-language:FR"></span></b></p>
<p class="MsoNormalCxSpMiddle" align="center" style="mso-margin-top-alt:auto;
mso-margin-bottom-alt:auto;mso-add-space:auto;text-align:center;line-height:
normal"><b><span lang="EN-GB" style="font-size:10.0pt;font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB;mso-fareast-language:FR">E-mail address: mathias.lavie-richard(at)inra.fr</span></b><b><span lang="EN-US" style="font-size:10.0pt;font-family:Arial;mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-US"></span></b></p>
Job Title Post-doc position: Impact of a fungal probiotic on the gut microbiota in basal, and induced dysbiotic environments
Post Details
Email mathias.lavie-richard(at)inra.fr
Employer's Website www.micalis.fr
Category
Job Discipline Job Discipline -> Biology
Job Classification Job Classification -> Postdoctoral Researcher
Job Type Job Type -> Full-time
Location Jouy en Josas, France
Key Words Postdoc, microbiota, immunology, host
Start Date February 2019
Salary 30-35k
Deadline Feb-15-2018