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PhD position in Drosophila developmental biologyPosted by: Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic
Posted date: Apr-30-2018
Location: Ceske Budejovice (Budweis), Czech Republic
Laboratory: Laboratory of developmental biology, dr. Alena Krejci, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech republic
http://www.prf.jcu.cz/en/kmb/research/research-group s/laboratory-of-developmental-biology.ht ml
We aim to dissect the interplay between metabolism and major signalling pathways, with the emphasis on Notch signalling pathway.
Project: Metabolic stress as regulator of Notch signalling
The Notch pathway has been described in several contexts to regulate glycolytic as well as mitochondrial metabolism (including paper from our lab Slaninova V, Open Biology, 2016). At the same time, recent evidence suggest that Notch pathway activity is sensitive to the cell metabolic parameters, such as the NAD:NADH ratio, amino acid availability or activity of metabolism related signalling pathway such as mTOR (Horvath M, Biochem J, 2016 and our current paper in preparation). We investigate this interplay using Drosophila wing disc, eye disc and immune system as models. The PhD project will be directed to characterization of a previsouly unknown Notch targeted transcription factor that mediates crosstalk between Notch, metabolism and immunity.
Applicant: Applicant should have a degree in molecular or cellular biology. Previous experience with Drosophila, molecular biology techniques and/or confocal microscopy is welcome.
Position: PhD position is a part of the 4-year PhD program at the Department of molecular biology and genetics, University of South Bohemia. More details of the Department at http://www.prf.jcu.cz/en/kmb
Send your CV including address of two referees to akrejciprf.jcu.cz