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Postdoctoral fellowship - cell biology of prion infection

Posted by: University of Calgary

Posted date: Jan-30-2018

Location: Calgary, AB, Canada

Prion diseases are fatal and infectious neurodegenerative diseases such as Creutzfeldt-Jakob disease in humans and characterized by the accumulation of a misfolded isoform of the cellular prion protein, termed PrPSc.
The project aims at studying the effects of PrPSc accumulation in the endo-lysosomal pathway of infected neurons, in particular on vesicle trafficking and cargo recycling. The overall goal is to investigate a link to neurodegeneration and to identify new targets for therapy using prion infected neuronal cell lines, primary neurons, organotypic slice cultures and mouse models of prion disease.
The successful applicant is expected to take on a leading role in study design, establishing methods such as organotypic slice cultures, co-supervision of graduate and undergraduate students as well as drafting manuscripts and assist in writing grant proposals.
The candidate is has the opportunity and is expected to apply for postdoctoral fellowships depending on eligibility.

Required skills and experience:
- PhD in neuroscience, cell biology, biochemistry or related field within 2 - 3 years of graduation
- appropriate scientific knowledge in cell biology and confocal microscopy, demonstrated by publications
- excellent English language skills
- able to work independently and as part of a team

Application package:
- cover letter staging motivation and interest for the topic
- CV including a list of publications with links
- a list with names of three references

Please send your application to sgilch(at)ucalgary.ca, Assistant Professor and Canada Research Chair in Prion Disease Research. For more information, see http://www.ncbi.nlm.nih.gov/pubmed/?term=gilch+s and visit our lab website www.ucalgary.ca/gilchlab.

About the University of Calgary
The University of Calgary is a leading Canadian university located in the nation‚s most enterprising city. The university has a clear strategic direction to become one of Canada‚s top five research universities by 2016, where innovative teaching and groundbreaking research go hand in hand, and where we fully engage the communities we both serve and lead. The strategy is called Eyes High, inspired by our Gaelic motto, which translates to ‚I will lift up my eyes.‚

To succeed as one of Canada‚s top universities, where new ideas are created, tested and applied through first-class teaching and research, the University of Calgary needs more of the best minds in our classrooms and labs. We‚re increasing our scholarly capacity by investing in people who want to change the world, bringing the best and brightest to Calgary to form a global intellectual hub and achieve advances that matter to everyone.

About Calgary
Named a cultural capital of Canada and one of the best places to live in the world, Calgary is a city of leaders ‚ in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city. Calgary is less than an hour‚s drive from the majestic Rocky Mountains and boasts the most extensive urban pathway and bikeway network in North America.
Job Title Postdoctoral fellowship - cell biology of prion infection
Post Details
Email sgilch(at)ucalgary.ca
Employer's Website www.ucalgary.ca
Job Discipline Job Discipline -> Cell Biology
Job Classification Job Classification -> Postdoctoral Researcher
Job Type Job Type -> Full-time
Location Calgary, AB, Canada
Key Words postdoc, prion, cell biology, therapy, Creutzfeldt-Jakob disease, protein misfolding disease, prion-like disease
Start Date May - June, 2018
Deadline Mar-01-2018