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PhD in Drosophila developmental biology

Posted by: Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic

Posted date: Dec-14-2017

Location: Ceske Budejovice (Budweis), Czech Republic

In the lab we aim to dissect the interplay between metabolism and major signalling pathways, with emphasis on the Notch signalling pathway.

ProjectMetabolic stress as regulator of Notch signalling

The Notch pathway has been described in several contexts to regulate glycolytic as well as mitochondrial metabolism. At the same time, recent evidence suggest that Notch pathway is sensitive to the cell metabolic parameters, such as the NAD:NADH ratio, amino acid availability or activity of metabolism related signalling pathway such as mTOR. We investigate this interplay using Drosophila wing disc, eye disc and immune system as our models. The theme of the PhD project can be defined according to the PhD student previous experience and interests, but it could be directed to characterization of mitochondria as regulators of Notch directed proliferation, to identification of binding sites for Notch targeted transcription factor involved in metabolism or to investigation of the NAD:NADH ratio as regulator of cell signalling.

Applicant: Applicant should have a degree in molecular or cellular biology. Previous experience with Drosophila, molecular biology techniques and/or confocal microscopy is welcome. 

Position: PhD position is a part of the 4-year PhD program at the Department of molecular biology and genetics, University of South Bohemia. 


Send your CV including address of two referees to akrejci(at)prf.jcu.cz


Job Title PhD in Drosophila developmental biology
Post Details
Email akrejci(at)prf.jcu.cz
Employer's Website kmb.prf.jcu.cz
Job Discipline Job Discipline -> Cell Biology
Job Classification Job Classification -> Other
Job Type Job Type -> Full-time
Location Ceske Budejovice (Budweis), Czech Republic
Key Words PhD, Drosophila,signaling, metabolism
Start Date 1.3.2017