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Postdoctoral FellowPosted by: Universite libre de Bruxelles
Posted date: Oct-24-2017
Location: Brussels, Belgium
The recently established Signal Transduction and Metabolism Laboratory led by Dr Esteban Gurzov is seeking highly motivated postdoctoral researchers to develop novel imaging methods to diagnose autoimmune diabetes, and to explore the pathophysiological mechanisms contributing to the development of obesity and type 2 diabetes. The successful applicants will join the ULB Center for Diabetes Research, characterised by an impressive track record in research excellence.
The study and diagnosis of early type 1 diabetes is currently hampered by a lack of reliable techniques to detect and quantify insulin producing β-cell mass in the pancreas. Therefore, there is an urgent need to develop imaging probes that would enable reproducible in vivo assessment of β-cells.
A postdoctoral position is available to characterise novel β-cell biomarker-binding molecules. These β-cell markers have a strong innovative use in islet research where they can be used to track β-cells both in vitro and in vivo. He/she will use bioinformatics analysis, structural biology and in vitro and in vivo approaches to develop and test insulin and additional markers for β-cell detection.
Project Area 2:
Protein tyrosine phosphatases (PTPs) constitute a superfamily of enzymes that dephosphorylate tyrosine-phosphorylated proteins to oppose the actions of protein tyrosine kinases. Our previous studies and preliminary data suggest that PTPs act as molecular switches for key signalling events in the development of metabolic disorders.
A postdoctoral position is available to fully characterise the activity of key PTPs in metabolic relevant cells in obesity and diabetes. Importantly, these functions of PTPs make them promising drug candidates for the treatment of metabolic disorders. Thus, our work will provide molecular mechanisms to propose novel pre-clinical approaches to treat these pathologies.
- Laboratory experience in metabolism and/or diabetes.
- Experience in biochemistry, molecular biology, primary cell culture, imaging and mouse work is desirable.
- High motivation, flexibility as well as innovate and creative thinking are a must.
- Excellent skills in spoken and written English.
Duration: 1 yr in the first instance
Applications should include:
- A cover letter describing research interests, previous experience and intended career path.
- Contact information for at least two academic references.
Dr. Esteban Gurzov