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Postdoctoral Research Fellow Translational Research in Breast CancerPosted by: UT Southwestern Medical Center
Posted date: Oct-13-2017
Location: Dallas, TX
Translational Research in Breast Cancer
The laboratory of Carlos L. Arteaga, MD in the Harold C. Simmons Comprehensive Cancer Center of UT Southwestern Medical Center is recruiting Postdoctoral Research Fellows.
a. Discovery of mechanisms of resistance to antiestrogen therapy in breast cancer
b. Genomic profiling of drug-resistant ER+ and triple negative breast cancer
c. Mechanism of action of gain of function oncogenes in breast cancer and their use as predictive
biomarkers of response to targeted therapies
d. Mechanisms of action of and resistance to rational combinations of targeted therapies in breast cancer (focus on PI3K/AKT, mutant ERBB receptors, TGFï¢, ERÎ±, FGFR, CDK4)
Methods include gain-of-function ORF genome screens, next gen DNA sequencing, single cell RNAseq, structural modeling, shRNA and CRISPR screens, functional small animal imaging, molecular profiling
and discovery using primary tumors from patients in clinical trials with targeted therapies, and studies with cell lines and xenografts (cell line and patient derived) using conditional shRNAs and targeted therapies in clinical development both in vitro and in vivo.
Recent relevant publications from the laboratory include:
a. Sci Transl Med. 2017 Aug 9;9(402). pii: eaai7993. doi: 10.1126/scitranslmed.aai7993; PMID:
b. Clin Cancer Res. 2017 Jul 27. doi: 10.1158/1078-0432.CCR-17-1232. [Epub ahead of print]; PMID:
c. Sci Transl Med. 2016 Apr 13;8(334):334ra53. doi: 10.1126/scitranslmed.aad3001; PMID: 27075627
d. Cancer Discov. 2017 Jun;7(6):575-585. doi: 10.1158/2159-8290.CD-16-1431. Epub 2017 Mar 8; PMID: 28274957
Applicants with a PhD, MD, or MD/PhD degree and a strong background in molecular biology and
genomics with a strong interest in translational research are encouraged to apply.
Please forward your CV and names of two references to:
Carlos L. Arteaga, MD Professor of Medicine
Director, UTSW Harold C. Simmons Comprehensive Cancer Center Lisa K. Simmons Distinguished Chair in
Comprehensive Oncology Associate Dean of Oncology Programs
5323 Harry Hines Blvd.
Dallas, TX 75390-8590
carlos.arteagautsouthwestern.edu Tel. 214-648-1677
UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women,
minorities, veterans and individuals with disabilities are encouraged to apply.