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PhD Position - Epigenetic Characterization of Cancer Associated Fibroblasts

Posted by: RWTH Aachen Medical School

Posted date: Sep-19-2017

Location: Aachen, Germany

The group Stem Cell Biology and Cellular Engineering at the Helmholtz-Institute for Biomedical Engineering is offering a position for a

Ph.D. student

Focus of this project is on epigenetic characterization of cancer associated fibroblasts (CAFs). These cells have crucial impact on tumorigenesis and metastasis. However, the cellular origin of CAFs and their epigenetic characteristics are largely unclear. We will analyze CAFs in hepatocellular carcinoma and myeloproliferative neoplasms to determine their clonal composition and differentiation potential. Genome wide DNA methylation profiles will be analyzed to determine disease-associated epigenetic modifications in CAFs, their cellular origin, and their frequency in tumor samples. Close collaboration with bioinformaticians is essential to integrate additional genetic and epigenetic datasets (AG Ivan Costa; http://costalab.org). All relevant techniques are established in the lab (including culture expansion, differentiation assays, flow cytometry, immunofluorescence and confocal microscopy, qRT-PCR, blotting techniques, genetic modifications, microarray platforms, single cell RNA-seq, and epigenetic analysis with deep sequencing technology). RWTH Aachen University Medical School wants to strengthen research in oncology. The project is embedded into an IZKF-funded research consortium "mesenchymal interactions and fibrogenic signalling in cancer development: molecular mechanisms in solid and hematologic neoplasms‚.

We are looking for a highly motivated and ambitious PhD student with a strong background in cell biology. Experience in stem cell biology and/or epigenetics would be appreciated. Willingness for teamwork, the ability to work independently, and excellent English language skills are prerequisites.

We offer a highly interactive and well equipped environment in a team with international partners, a broad spectrum of methods, and a highly relevant topic. (homepage: http://www.stemcellbiology.ukaachen.de)

Funding is initially available for three years: for the first year with 50% TV-L E13 and for the second and third year with 65% TV-L E13.

The University RWTH Aachen supports women in science. Applications of handicapped applicants are encouraged.

Your application should include a cover letter which specifically emphasizes your interest in our work (in English), CV, and copies of the most important certificates. For additional questions please contact Prof. Dr. Dr. Wolfgang Wagner. Your application should be send by Email (wwagner(at)ukaachen.de) until October 15th, 2017.

We are looking forward to your application!
Job Title PhD Position - Epigenetic Characterization of Cancer Associated Fibroblasts
Post Details
Email wwagner(at)ukaachen.de
Employer's Website www.stemcellbiology.ukaachen.de
Job Discipline Job Discipline -> Cancer/Oncology
Job Classification Job Classification -> Other
Job Type Job Type -> Full-time
Location Aachen, Germany
Key Words PhD student, stem cell, cancer, epigenetic
Start Date January 1st 2017
Salary 50% TV-L E13 for first year; 65% TV-L E13 for second and third year
Deadline Oct-15-2017