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Postdoctoral Position in Regenerative BiologyPosted by: University of California San Francisco
Posted date: Nov-02-2016
Location: San Francisco, CA
We are seeking highly motivated candidates with interests in regenerative biology to join Dr. Huang‚s laboratory at UCSF. The laboratory uses the heart as a model system and an entry point to investigate organ development, regeneration and repair in adult zebrafish, neonatal and adult mice, with an emphasis on the pathways that regulate resident stem cell activation and mature cell dedifferentiation/proliferation, and with innovative and integrated approaches in engineering, single cell analysis, advanced imaging microscopy and genome manipulation technology.
1. Developing novel intravital imaging in live animals and tissue clearing techniques for high-resolution visualization of cellular behavior, activity and interaction during heart development, regeneration and injury repair.
2. Performing unprecedented functional screens to induce adult mouse cardiomyocyte regeneration using both candidate gene and directed evolution approaches integrated with CRISPR/Cas9 genome manipulation technology.
3. Taking pharmacological and genetic approaches to uncover the unifying principle governing the decline of regenerative potentials in adult mammalian organs and appendages including the heart, digit/limb, skin, brain, and spinal cord.
4. Leveraging the power of phylogenetic screen to identify novel higher vertebrate animal models with extraordinary tissue regenerative capacity.
5. Investigating human genetic mutations and underlying molecular mechanisms in rare heart diseases that may result in preservation of cardiac regenerative potential.
We invite candidates with a highly productive training record, strong research motivation, and extensive experience in any of but not limited to the following areas: (1) developmental and regenerative biology, (2) heart physiology and cardiomyocyte biology, and (3) cell division and signaling. Successful candidate will work in a highly interdisciplinary research program that interfaces developmental and stem cell biology, regenerative medicine, and cardiovascular diseases.
To apply, interested candidates should submit a single PDF file including 1) a cover letter, 2) curriculum vitae, 3) a list of three references, and 4) a brief statement of research experience, interest, and career plan to Dr. Huang (Guo.Huangucsf.edu, please delete one when contacting Dr. Huang).
Guo Huang, Ph.D.
Investigator of the Cardiovascular Research Institute & Department of Physiology
Investigator of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Lab website: http://www.cvri.ucsf.edu/~huang/lab/Research.htm l
1. Huang, G. N., Thatcher, J. E., McAnally, J., Kong, Y., Qi, X., Tan, W., DiMaio, M., Amatruda, J. F., Gerrard, G., Hill, J. A., Bassel-Duby, R. & Olson, E. N. (2012) C/EBP transcription factors mediate epicardial activation during heart development and injury. Science (Research Article). 338 (6114): 1599-1603.
2. Song, K., Nam, Y., Luo, X., Qi, X., Tan, W., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Nelson, E. G., Hill, J., Bassel-Duby, R. & Olson, E. N. (2012) Heart repair by expression of cardiac transcription factors in non-cardiomyocytes in vivo. Nature (Research Article). 485(7400):599-604.
3. Huang, G. N., Huso, D., Bouyain, S., Tu, J., McCorkell, K. A., May, M. J., Zhu Y., Lutz M., Collins S., Dehoff M., Kang S., Whartenby, K., Powell J., Leahy, D., and Worley, P. F. (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 319 (5862): 476-81.
4. Huang, G. N*., Zeng, W., Kim*, J. Y., Yuan, J.P., Han, L., Muallem, S. & Worley, P. F. (2006) STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nature Cell Biology. 8(9): 1003-10.