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Postdoctoral FellowPosted by: THOMAS PULINILKUNNIL
Posted date: Oct-24-2016
Location: Saint John, NB, CA
A full-time grant paid postdoctoral position for two years is available starting January 2017 for a highly motivated individual to study Lysosomal signaling, metabolism and function in the laboratory of Dr. Thomas Pulinilkunnil Faculty of Medicine, Dalhousie University New Brunswick Campus.
Project Description: Pulinilkunnil laboratory is studying the metabolic underpinning of dysregulated lysosomal function.
Project 1: Proteotoxic Basis for Metabolic Heart Disease:
Recent studies from our laboratory demonstrated that aberrant lysosomal function impact mitochondrial metabolism and energetics thus governing cardiovascular outcomes in biology and disease (Biochim Biophys Acta. 2016 Sep 9;1861(12 Pt A):1893-1910; Biochem J. 2016 Aug 3. pii: BCJ20160385). Using a multispecies approach (rodents, yeast and zebrafish), Pulinilkunnil lab intends to examine molecular mechanisms by which nutrients (glucose, fat and amino acids) influence lysosomal function to alter autophagic protein degradation.
Project 2: Lysosome Nutrient Sensing and Metabolism in Cancer Pathogenesis:
Abnormalities in cellular metabolism augment autophagy to facilitate cancer cells to precipitously adapt to environmental stressors by evading demise by chemotherapy. Our laboratory is currently elucidating the mechanisms by which tumor cell metabolism signals changes in lysosomal autophagy to influence the outcomes of chemotherapy. By specifically examining the cross talk between mitochondria and lysosome we hope to uncover novel biochemical pathways that could be targeted selectively to render cancer cells susceptible to first line cancer treatment.
Qualification and skills: The applicants must have completed a Ph.D. in biomedical sciences or other related disciplines within the last three years with impressive publication record to be competitive for provincial and national scholarships. Candidate must have a strong background/training in energy metabolism, cellular and molecular biology and physiology. Furthermore expertise in cardiac perfusion, surgeries, animal handling, cell culture, cell and molecular biology, mouse transgenesis is essential. Molecular cloning, plasmid production, Westerns, Q-PCR, next generation sequencing, RNAi methodology, gene editing methodologies is highly desirable. Candidate must demonstrate intellectual and working independence and exhibit absolute proficiency in spoken and written English.
Duties and responsibilities: This PDF position will require a significant amount of in-vivo, in-vitro, immunological and molecular studies. However, importantly it will provide unique opportunities for intellectual input, opportunities for personal development and to work in a vibrant translational research area.
Procedure to apply: Please submit a single PDF package containing a cover letter, CV, publication record and one page detailing expertise, research interests/career goals, and contact information for three referees to Dr. Thomas Pulinilkunnil (tpulinildal.ca). Application will be accepted until 4.00 pm, December 05, 2016 and no formal acknowledgement to the applicants will be sent. Canadian citizens and permanent residents will be preferred for this position. Applications will be reviewed until the positions are filled.