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Post-doctoral Fellowship in Skin Microbiom Studies

Posted by: Genome Institute of Singapore

Posted date: Oct-14-2016

Location: Singapore

  

We are looking for genomics researchers with a keen interest in studying the role of microbes in skin diseases. The Nagarajan lab in the Genome Institute of Singapore, in collaboration with the Epithelial Biology group in the Institute of Medical Biology are seeking candidates to lead multiple projects studying the role of the microbiome in inflammatory diseases of the skin (e.g. eczema, psoriasis etc.). Successful candidates will have the opportunity to design new studies in close interaction with doctors and domain experts, applying nextgen omics and analytical approaches to understand the complex host-microbiome interactions that lead to skin disease [1].

 The role that microbes play on human skin is still poorly understood despite characterization of the diversity of habitats and niches that they occupy [2]. This is particularly the case for skin diseases which can affect a large proportion of the population and have a significant impact on their quality of life. We recently conducted a metagenome-wide association study for eczema, identifying key microbes and their likely functional roles [1]. We are interested in extending this work in several directions including (i) characterizing the utility of pre-/probiotic therapies (ii) developing in vitro and in silico models for host-microbiome interactions [3] and (iii) studying the role of fungi (e.g. Malassezia) on human skin [4].

 

Qualifications

PhD in Computational Biology/Computer Science/Applied Mathematics/Genomics

•Strong analytical and programming skills (C/C++, perl/python, UNIX environment). Candidates with significant experience in Microbiome Studies or Skin Biology will be strongly preferred.

 

How To Apply:

E-mail cover letter, research statement, curriculum vitae, and contact details of at least three referees to Niranjan Nagarajan (gis.a-star.edu.sg">nagarajann(at)gis.a-star.edu.sg)

 

References

1.       Chng KR, Tay ASL, Li C, Ng AHQ, Wang J, Suri BK, Matta AS, McGovern N, Janela B, Wong XFC, Sio YY, Au BV, Wilm A, De Sessions PF, Lim TC, Tang MBY, Ginhoux F, Connolly JE, Lane EB, Chew FT, Common JEA#, Nagarajan N# "Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare" Nature Microbiology 2016 1:16106 doi:10.1038/nmicrobiol.2016.106

2.       Oh, J. et al. "Biogeography and individuality shape function in the human skin metagenome." Nature 2014 514, 59–64

3.       Li C, Lim KM, Chng KR, Nagarajan N# "Predicting microbial interactions through computational approaches." Methods 2016 Jun 1 ; 102 : 12-9 Epub 2016 Mar 26

4.       Wu G, Zhao H, Li C, Rajapakse MP, Wong WC, Xu J, Saunders CW, Reeder NL, Reilman RA, Scheynius A, Sun S, Billmyre BR, Li W, Averette AF, Mieczkowski P, Heitman J, Theelen B, Schröder MS, De Sessions PF, Butler G, Maurer-Stroh S, Boekhout T, Nagarajan N#, Dawson TL# "Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin." PLoS Genet 2015 Nov ; 11(11) : e1005614 Epub 2015 Nov 5

Job Title Post-doctoral Fellowship in Skin Microbiom Studies
Post Details
Email nagarajann(at)gis.a-star.edu.sg
Employer's Website www.a-star.edu.sg
Category
Job Discipline Job Discipline -> Computational Biology
Job Classification Job Classification -> Postdoctoral Researcher
Job Type Job Type -> Full-time
Location Singapore
Key Words postdoc, computational biology
Start Date 14 Oct 2016
Deadline Mar-31-2017