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Associate Investigator: Cancer Genetics, Epigenetics and BiomarkersPosted by: Baylor Scott & White Research Institute
Posted date: Jun-07-2016
Location: Dallas, TX, USA
An Associate Investigator position is available for immediate recruitment for a highly motivated candidate to join a team of researchers at the Baylor Scott & White (BSW) Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA. The laboratory headed by Dr. Ajay Goel, PhD focuses on understanding the interplay between genetic and epigenetic alterations in gastrointestinal and other human cancers. We are a multidisciplinary research group, undertaking a number of collaborative projects involving Baylor Research Institute and large international consortia.
This position involves studies surrounding work in the field of epigenetics and noncoding RNA research. More specifically, the projects will involve any/all of the following research focuses.
a) Exploration of the role of aberrant DNA methylation, histone modifications and non-coding RNAs (miRNA, lncRNAs, snoRNAs, circRNAs, piRNAs etc.) in colorectal, pancreatic, gastric, esophageal, hepatocellular and other cancers.
b) Establishment of innovative methodologies for the development of epigenetic and non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal and non-GI cancers.
c) A better understanding of the translational and clinical role of genetic and epigenetic signatures in cancers.
d) Interest and/or experience with exosomal and microvesicular biomarkers
e) Understanding the genetic basis of early-onset and familial cancers.
f) Chemoprevention of cancers using dietary nutraceuticals, non-steroidal anti-inflammatory drugs (NSAIDs), and other drugs.
g) Molecular mechanisms of cancer chemotherapy, stem cells, chemoresistance and chemosensitization.
h) Gut microbiome, and its influence on gastrointestinal cancers.
An ideal candidate should have a strong background in molecular biology, and relevant experience in cancer genetics and epigenetics. The candidates with prior hands-on experience in NGS-based platforms (Ion Torrent PGM sequencer, MiSeq/HiSeq, RRBS, ChIP-Seq, MeDip and RNASeq etc.), and other array-based platforms will be given preference. Knowledge and experience with various bioinformatics and biostatistical analysis tools will be highly preferred.
The Associate Investigator is a high-level position for an individual who is a self-sustaining Scientist and has achieved recognition in his/her field of endeavor. He/she heads a laboratory that focuses its research in an area that is compatible with goals of the BSW Research and meets with the approval of the Center for Cancer Research Director. The Associate Investigator is responsible for hiring, training and management of his/her lab personnel and for assuring that they work according to the BSW Research standards. While the Associate Investigator may receive supplemental funds from BSW Research, it is the Associate Investigator’s responsibility to obtain grants that will support his/her research and to produce data that is worthy of publication in leading scientific journals and has patent potential. The Associate Investigator is a member of the BSW Research faculty and plays a role in the continued growth and development of BRI. He/she may be asked to serve on committees, develop collaborations or act as a liaison with external departments. An Associate Investigator may be promoted to the level of Investigator once he/she has obtained at least three grants of a specified nature and/or achieved recognition as a leader in his/her field.
Minimum Requirements: The candidate should possess the following criteria: 1) PhD, MD/PhD 2) Evidence of first author peer-reviewed publications and prior grant funding success, 3) Prior molecular and/or cancer biology experience and evidence of project development, 4) Excellent communication and writing skills. Prospective candidates should be highly motivated, enthusiastic about science, with an ability to think creatively and independently. Candidate should demonstrate a strong track record of publication, have good organizational, written, and oral communication skills, and be able to work independently and in a team environment.
To Apply: Salary is commensurate with experience. Interested candidates should submit a CV and cover letter summarizing your Qualifications, Research Interests and Career Goals, and describe your specific interest in our lab. Include the names and contact information of 3 references and send via email to: Investigator/Professor Director, Center for Gastrointestinal Research Director, Center for Epigenetics, Cancer Prevention and Cancer Genomics Baylor Scott&White Research Institute and Charles A. Sammons Cancer Center 3410 Worth Street, Suite 610 Dallas, TX 75246 Phone: 214-820-6852 (Office) 214-820-2603 (Direct) Fax: 214-818-9292 Web address: http://www.baylorhealth.edu/GiResearch
Director, Center for Gastrointestinal Research
Director, Center for Epigenetics, Cancer Prevention and Cancer Genomics
Baylor Scott&White Research Institute and Charles A. Sammons Cancer Center
3410 Worth Street, Suite 610
Dallas, TX 75246
Phone: 214-820-6852 (Office)
Web address: http://www.baylorhealth.edu/GiResearch