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Scientist - Protein Biochemistry - 1433Posted by: RegeneronPosted date: Apr-06-2009
Location: Tarrytown, NY 10591
Located in the beautiful Hudson Valley region of New York, Regeneron is a biopharmaceutical Company that discovers, develops, and commercializes therapeutic medicines for the treatment of serious medical conditions. Regeneron currently markets ARCALYST™ (rilonacept) Injection for subcutaneous use for the treatment of a rare, inherited, inflammatory condition. The company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases and inflammatory diseases, and has preclinical programs in other diseases and disorders.
With a strong research base and product focus, Regeneron is able to understand thoroughly the biology of specific disease states, discover potential therapeutic candidates and evaluate product candidates in clinical trials. Regeneron has developed several proprietary platform technologies, which it has incorporated into a comprehensive system that allows it to accelerate the discovery and design of fully human antibodies and move these candidates rapidly into clinical development.
Job Title: Scientist - Protein Biochemistry
Requisition Number: 1433
Location: Tarrytown, NY 10591
We are seeking a biophysical chemist to join out team in protein biochemistry group within the chemistry and pre-clinical development department. The qualified candidate is expected to take a leading technical role in developing biophysical and biochemical assays to support the characterization of protein therapeutics in pre-clinical and clinical programs. In depth expertise in protein characterization is required and includes spectroscopic techniques (light scattering, fluorescence, circular dichroism), protein purification and characterization, and assay development. Candidates should possess strong communication skills and be motivated, proactive and capable of managing multiple projects.
50% Research support for preclinical and clinical programs
-Candidate will be responsible for providing biochemical and biophysical characterization of drugs in late stage and pre-clinical or clinical programs to support comparability studies and CMC sections of INDs and BLAs. The candidate is expected to provide input on experimental designs and suggest modifications technical tasks effectively with limited guidance, involving a range of techniques and should be able to independently troubleshoot problems with methods and protocols.
50% Method and technology development
-The candidate is expected to conduct novel research projects that can lead to either peer-reviewed publications or increased value in the technical proficiencies of the group. These projects will focus on developing novel biochemical/biophysical assays or improving existing ones. Results from these projects will help in the advancement of future therapeutic programs. The candidate is expected to develop these projects fairly independently and to present the progress and future directions to peers and supervisors regularly.
Technical Skills:
Technical proficiencies include protein purifications, chromatography, electrophoresis (SDS-PAGE, Western blot, 2-D gels) and protein modification (chemical and enzymatic). CE and/or MALLS experience is a plus.
Requirement:
Position requires a Ph.D. in biochemistry or biophysical chemistry or related field plus 2-4 years postdoctoral experience with a record of scientific achievements, creativity, and excellent communication skills (oral and written). Good analytical techniques, excellent communication skills, and the ability to work independently and in a team-oriented environment. Candidate should be able to multi-task and work well under pressure.
Please send your applications to:
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