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Institute Sr Research Scientist - Cancer BiologyPosted by: MD Anderson Cancer Center
Posted date: Mar-23-2016
Location: Houston, TX
The mission of The Center for Co-Clinical Trials (CCCT) is to integrate biological insights with drug discovery expertise to accelerate the development of innovative targeted cancer therapeutics for unmet oncology needs. The CCCT partners with the Institute for Applied Cancer Science (IACS) to integrate ground-breaking translational research teams with world-class drug discovery scientists while leveraging a state of the art computational biology infrastructure, unparalleled access to patient samples and an industry seasoned in vivo pharmacology unit. The CCCT’s cross functional teams aim to deliver biological insights to enable rapid translation of novel agents and therapeutic regimens to the clinic targeting the most responsive patients. As part of the MD Anderson Cancer Center Moon Shot initiative, we have created an exceptional, integrated environment where industry seasoned scientists work side by side with highly successful academic scientists and clinicians. We are seeking the most dedicated, highly motivated individuals who will help us reach our goal of delivering safer, more effective treatments to our patients.
The Institute Senior Research Scientist leads cross-functional research teams to identify and validate novel oncology targets, drive drug discovery biology and translate these findings into novel oncology therapeutic agents to benefit defined patient populations. The candidate will be a highly creative cancer biologist with a strong desire to succeed at the highest level.
The Senior Research Scientist will
- Lead efforts to identify and validate novel drug targets for the development of small molecule therapeutics.
- Lead program biology efforts to enable selection of lead candidate molecules and transition into clinical development.
- Apply expertise in cancer biology, genomics, and drug discovery to advance programs.
- Lead collaborations with computational biologists to identify deregulated contexts utilizing patient derived samples and –omic databases to inform on target discovery, validation, drug development and testable clinical context hypotheses.
- Lead and guide the design, execution and interpretation of in vitro, ex-vivo and in vivo studies to validate drug targets, advance compound selection and explore therapeutic potential of drug targets.
- Coordinate the design and development of cell and molecular assays to define mechanism of action for compounds and pharmacodynamic assays to be used in pre-clinical and clinical setting.
- Develop extensive knowledge and experience in key areas of tumor biology including, but not limited to immune oncology, oncogenic signaling, tumor microenvironment, metabolism, epigenetic deregulation or apoptosis.
- Lead and manage strong collaborative relationships.
- Manage activity of direct reports.
- Lead the development and application of cutting edge basic science tools and methodologies to enable Center projects.
- Interpret, present and report research findings at internal and external scientific meetings.
Required experience: With Master’s degree, at least eleven years of research laboratory experience; with Ph.D. degree, at least five years of preferred experience.
The ideal candidate will:
- Evidence of experience in a pharmaceutical/biotech environment.
- Extensive knowledge and experience in aspects of key areas of tumor biology such as immune oncology, oncogenic signaling, tumor microenvironment, cancer metabolism, epigenetic deregulation or apoptosis. Publications in top peer-reviewed journals.
- Evidence of incorporation of cancer genetics to inform on target discovery, validation or clinical development of drug candidates.
- Extensive experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study drug target biology.
- Experience utilizing genetically engineered mouse models and orthotopic or subcutaneous primary or established tumor cell line xenograft models.
- Evidence of experience of being the lead biologist on a cross-functional team of chemists, in vitro and in vivo pharmacologists to develop and utilize assays for the development of small molecule inhibitors.
- Evidence of exceptional data analysis skills, ability to interpret results and contribute to the design of follow-up experiments, troubleshoot issues, and effectively present to co-workers, collaborators and senior leadership.
- Evidence of independent thinking, people management with strong leadership and communication skills.
- Ability to work well under pressure to drive projects and meet critical timelines.
- Experience managing one or more multi-functional teams of scientists to deliver on program objectives.